Rare Case of Malignant Transformation of Pulmonary Hamartoma

Abstract

We reported a rare case of malignant transformation in a pulmonary hamartoma observed in a 48-year-old female. The hamartoma was incidentally identified with the presence of fat attenuation component. Subsequent imaging during follow-up revealed a significant loss of fat content accompanied by an increase in solid components within the nodule. The patient remained asymptomatic for respir-atory or systemic issues. An interventional radiology-guided CT biopsy was performed, and histo-pathological analysis confirmed the presence of a lipid-rich adenocarcinoma. This case underscores the importance of vigilant monitoring and consideration of malignant transformation in pulmonary hamartomas.